Assignment 1:

1.  In each scenario below, predict whether an action potential will be produced.  The resting membrane potential of the postsynaptic membrane is -70 mV.

        a.  15 neurons synapse on one postsynaptic neuron.  12 of the neurons produce EPSPs of 2 mV each, and the other three produce IPSPs of
                3 mV each.  The threshold for the postsynaptic cell is -50 mV.
 

        b.  15 neurons synapse on one postsynaptic neuron.  14 of the neurons produce EPSPs of 2mV each, and the other one produces an IPSP of 9 mV.  The
threshold for the postsynaptic cell is -50 mV.

2.  In myasthenia gravis, there is a specific loss of neurotransmitter receptors at the neuromuscular junction.
    a.  What is the neurotransmitter?
    b.  What kind of receptors are lost?
    c.  What kinds of drugs might you use to treat this condition?

3.  You are driving home from Advanced Human Physiology late one Tuesday night when you see 3 deer leaping across the road in front of you.  You slam on
your brakes and  avoid hitting the deer.

    a.  Trace the afferent and efferent pathways involved, including effects on both somatic and autonomic nervous system.  Be sure to identify neurotransmitters
involved and their receptors where known.

    b.  Arriving home moments later, you quickly exit your car.  In your agitation, you twist your ankle.  You start taking a non-steroidal anti-inflammatory drug to
manage the pain.  What is the mechanism of action of this drug?